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LNP023 hydrochloride

CAS No. 1646321-63-2

LNP023 hydrochloride( Iptacopan HCl )

Catalog No. M23738 CAS No. 1646321-63-2

LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LNP023 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM.
  • Description
    LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.
  • In Vitro
    ——
  • In Vivo
    Animal Model:C57BL/6 mice with KRN-induced arthritis Dosage:20, 60, and 180 mg/kg Administration:Orally gavaged; twice a day (b.i.d.) for 14 days Result:Blocked KRN-induced arthritis.
  • Synonyms
    Iptacopan HCl
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    factor B
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1646321-63-2
  • Formula Weight
    458.98
  • Molecular Formula
    C25H31ClN2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (544.69 mM; Need ultrasonic);H2O:50 mg/mL (108.94 mM; ultrasonic and warming)
  • SMILES
    O=C(O)C1=CC=C([C@H]2N(CC3=C(OC)C=C(C)C4=C3C=CN4)CC[C@H](OCC)C2)C=C1.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dimitrios C Mastellos, et al. Expanding Complement Therapeutics for the Treatment of Paroxysmal Nocturnal Hemoglobinuria. Semin Hematol. 2018 Jul;55(3):167-175.
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